Open lung approach vs acute respiratory distress syndrome network ventilation in experimental acute lung injury.

ABSTRACT:

Background

Setting and strategies of mechanical ventilation with positive end-expiratory pressure (PEEP) in acute lung injury (ALI) remains controversial. This study compares the effects between lung-protective mechanical ventilation according to the Acute Respiratory Distress Syndrome Network recommendations (ARDSnet) and the open lung approach (OLA) on pulmonary function and inflammatory response.

Methods

Eighteen juvenile pigs were anaesthetized, mechanically ventilated, and instrumented. ALI was induced by surfactant washout. Animals were randomly assigned to mechanical ventilation according to the ARDSnet protocol or the OLA (n=9 per group). Gas exchange, haemodynamics, pulmonary blood flow (PBF) distribution, and respiratory mechanics were measured at intervals and the

SUBMITTER: Spieth PM 

PROVIDER: S-EPMC9174723 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature