Gene Expression Profiles of the Aging Rat Hippocampus Imply Altered Immunoglobulin Dynamics.

ABSTRACT: Aging is a process that leads to the deterioration in physiological functioning of the brain. Prior research has proposed that hippocampal aging is accompanied by genetic alterations in neural, synaptic, and immune functions. Nevertheless, interactome-based interrogations of gene alterations in hippocampal aging, remain scarce. Our study integrated gene expression profiles of the hippocampus from young and aged rats and functionally classified network-mapped genes based on their interactome. Hippocampal differentially expressed genes (DEGs) between young (5-8 months) and aged (21-26 months) male rats (Rattus norvegicus) were retrieved from five publicly available datasets (GSE14505, GSE20219, GSE14723, GSE14724, and GSE14725; 38 young and 29 aged samples). Encoded hippocampal protei

SUBMITTER: Giannos P 

PROVIDER: S-EPMC9174800 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature