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Direct C-H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide.

ABSTRACT: An efficient Cu-catalyzed strategy for the direct C-H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.

SUBMITTER: Zhang D

PROVIDER: S-EPMC9174840 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Direct C-H amination reactions of arenes with <i>N</i>-hydroxyphthalimides catalyzed by cuprous bromide.

Zhang Dongming D Lv Bin B Gao Pan P Jia Xiaodong X Yuan Yu Y

Beilstein journal of organic chemistry 20220603

An efficient Cu-catalyzed strategy for the direct C-H amination of arenes in high yields using <i>N</i>-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite. ...[more]

PMID: 35706994

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