Novel Single Nucleotide Polymorphisms (SNPs) and Genetic Features of the Prion Protein Gene (PRNP) in Quail (Coturnix japonica).

ABSTRACT: Prion diseases are fatal infectious diseases caused by conformational changes of a prion protein (PrP^Sc) derived from a normal prion protein (PrP^C). Prion diseases have been reported in several mammalian hosts but not in any birds, including the most popular poultry species, of which chickens showed some resistance to experimental prion infection. To identify the genetic polymorphisms in the quail prion protein gene (PRNP), polymerase chain reaction and DNA sequencing were performed with gene-specific primers in 164 quails. Four in silico programs, including PROVEAN, PANTHER, SIFT, and AMYCO, were used to investigate the effect of non-synonymous single nucleotide polymorphisms (SNPs) on quail PrP. Furthermore, to investigate the genetic relationship of a

SUBMITTER: Kim Y 

PROVIDER: S-EPMC9174905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature