Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction.

ABSTRACT:

Background

The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study.

Materials and methods

The single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED.

Results

Snoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence inte

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC9174907 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature