Bone Deleterious Effects of Different NRTIs in Treatment-naive HIV Patients After 12 and 48 Weeks of Treatment.

ABSTRACT:

Background

Bone alterations have been observed in the course of HIV infection, characterized by a marked decrease in bone mineral density (BMD) and an increase in the frequency of fractures as a result of fragility. We aim to evaluate early changes in bone metabolic profile and the possible association with tenofovir and other nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) in treatment-naïve HIV patients.

Methods

We conducted a prospective study in naïve HIV-infected adults (under 50 years), separated into three groups according to NRTI therapy: tenofovir disoproxil fumarate (TDF); tenofovir alafenamide (TAF) and abacavir (ABC). BMD and epidemiological, immunological and metabolic bone parameters were evaluated. Bone markers were analyzed in plasma at bas

SUBMITTER: Atencio P 

PROVIDER: S-EPMC9175084 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature