Ontology highlight
ABSTRACT:
SUBMITTER: Miller-Rhodes P
PROVIDER: S-EPMC9175136 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Miller-Rhodes Patrick P Li Herman H Velagapudi Ravikanth R Chiang Wesley W Terrando Niccolò N Gelbard Harris A HA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20220601 6
Systemic perturbations can drive a neuroimmune cascade after surgical trauma, including affecting the blood-brain barrier (BBB), activating microglia, and contributing to cognitive deficits such as delirium. Delirium superimposed on dementia (DSD) is a particularly debilitating complication that renders the brain further vulnerable to neuroinflammation and neurodegeneration, albeit these molecular mechanisms remain poorly understood. Here, we have used an orthopedic model of tibial fracture/fixa ...[more]