Fatal pulmonary Scedosporium aurantiacum infection in a patient after near-drowning: A case report.

ABSTRACT:

Background and purpose

Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.

Case report

Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal. Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.

Conclusion

SUBMITTER: Ghasemian R 

PROVIDER: S-EPMC9175145 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature