Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity.

ABSTRACT:

Background

Lower-leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.

Objective

We aimed to study the effect of (1) lower-leg trauma and (2) knee arthroscopy on procoagulant phospholipid-dependent (PPL) activity plasma levels.

Methods

POT-(K)CAST trial participants who did not develop VTE were randomly selected for the current study. Plasma was collected shortly after lower-leg trauma or before and after knee arthroscopy. For aim 1, samples of 67 patients with lower-leg injury were compared with control samples (preoperative

SUBMITTER: Touw CE 

PROVIDER: S-EPMC9175257 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature