Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism.

ABSTRACT: Over the past decades, there have been tremendous efforts to understand the cross-talk between viruses and host metabolism. Several studies have elucidated the mechanisms through which viral infections manipulate metabolic pathways including glucose, fatty acid, protein, and nucleotide metabolism. These pathways are evolutionarily conserved across the tree of life and extremely important for the host's nutrient utilization and energy production. In this review, we focus on host glucose, glutamine, and fatty acid metabolism and highlight the pathways manipulated by the different classes of viruses to increase their replication. We also explore a new system of viral hormones in which viruses mimic host hormones to manipulate the host endocrine system. We discuss viral insulin/IGF-1-like pept

SUBMITTER: Girdhar K 

PROVIDER: S-EPMC9175272 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature