Association of thyroid dysfunction and autoantibody positivity with the risk of preterm birth: a hospital-based cohort study.

ABSTRACT:

Background

Evidence for the association of thyroid dysfunction and autoantibody positivity with preterm birth remains controversial. We aimed to study the association of maternal thyroid dysfunction and autoantibody positivity with the risk of preterm birth.

Method

A hospital-based cohort study of 40,214 women was conducted. Gestational age-specific percentiles of the FT4 and TSH concentrations were used for the definition of thyroid dysfunction. Autoantibody positivity was identified when the concentration > the threshold. The association of thyroid dysfunction and autoantibody positivity with the risk of preterm birth was estimated.

Results

No significant higher risk of preterm birth was found for women with variants of thyroid dysfunction or autoantibody positive t

SUBMITTER: Wu JN 

PROVIDER: S-EPMC9175335 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature