Glucosamine Use and Risk of Colorectal Cancer: Results from UK Biobank.

ABSTRACT:

Background

Use of the dietary supplement glucosamine has been associated with reduced risk of colorectal cancer; however, it remains unclear if the association varies by screening status, time, and other factors.

Methods

We therefore evaluated these questions in UK Biobank. Multivariable-adjusted HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression.

Results

No association was observed between use of glucosamine and risk of colorectal cancer overall (HR = 0.94; 95% CI, 0.85-1.04). However, the association varied by screening status (Pinteraction = 0.05), with an inverse association observed only among never-screened individuals (HR = 0.86; 95% CI, 0.76-0.98). When stratified by study time, an inverse association was observe

SUBMITTER: Kantor ED 

PROVIDER: S-EPMC9175387 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature