LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a clinically common malignant tumor worldwide. LukS-PV is the S component of Panton-Valentine leukocidin secreted by Staphylococcus aureus, which has shown anti-cancer activity. Based on previous findings, this study investigated the effects of LukS-PV on HCC migration and the potential molecular mechanisms involving acetylation pathways.

Methods

After treating HCC cells with different concentrations of LukS-PV, we used scratch assays to determine the mobility of the cancer cells. Western blots were used to determine the expression levels of migration-related proteins. Quantitative proteomic sequencing was used to evaluate proteomic changes in target proteins. Immunoprecipitation and liquid chromatography coupled with tandem mass

SUBMITTER: Xu X 

PROVIDER: S-EPMC9175482 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature