Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19.

ABSTRACT: Although vaccines have been evaluated and approved for SARS-CoV-2 infection prevention, there remains a lack of effective treatments to reduce the mortality of COVID-19 patients already infected with SARS-CoV-2. The global data on COVID-19 showed that men have a higher mortality rate than women. We further observed that the proportion of mortality of females increases starting from around the age of 55 significantly. Thus, sex is an essential factor associated with COVID-19 mortality, and sex related genetic factors could be interesting mechanisms and targets for COVID-19 treatment. However, the associated sex factors and signaling pathways remain unclear. Here, we propose to uncover the potential sex associated factors using systematic and integrative network analysis. The unique results

SUBMITTER: Li F 

PROVIDER: S-EPMC9175532 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature