Reposition of the Fungicide Ciclopirox for Cancer Treatment.

ABSTRACT:

Background

Ciclopirox (CPX), a broad-spectrum fungicide, has been widely used to treat fungal infection on the skin and nails for decades. Recent preclinical and clinical studies have shown that CPX also possesses promising anticancer activity.

Objective

The objective of this study is to summarize the patents, the pharmacological and toxicological properties, the anticancer activity, and the mechanisms of action of CPX and its derivatives as anticancer agents.

Methods

PubMed and Google using the keywords "ciclopirox", "cancer or tumor" and "patent" were searched, and the identified literature was reviewed.

Results

Pharmacological and toxicological profiles from preclinical and clinical studies support that systemic administration of CPX and its derivatives is f

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9175535 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature