Shared etiology of type 1 diabetes and Hashimoto's thyroiditis: a population-based twin study.

ABSTRACT:

Objective

Type 1 diabetes and Hashimoto's thyroiditis frequently cluster in individuals and in families, indicating shared origins. The objective of this study was to investigate familial co-aggregation of these diseases and to quantify shared genetic and environmental factors.

Design

This study is a twin cohort study.

Methods

National health registers were used to identify cases among 110 814 Swedish twins. Co-aggregation was calculated as risk ratios for type 1 diabetes among co-twins of individuals with Hashimoto's thyroiditis, and vice-versa. Variance explained by genetics (i.e. heritability), and the proportions thereof shared between the diseases, was estimated by contrasting associations in monozygotic and dizygotic twins using structural equation models.

Re

SUBMITTER: Skov J 

PROVIDER: S-EPMC9175555 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature