Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1.

ABSTRACT: The Dummerstorf high-fertility mouse line FL1 is a worldwide unique selection experiment for increased female reproductive performance. After more than 190 generations of selection, these mice doubled the amount of offspring per litter compared to the unselected control line. FL1 females have a superior lifetime fecundity and the highest Silver fecundity index that has been described in mice, while their offspring show no signs of growth retardation. The reasons for the increased reproductive performance remained unclear. Thus, this study aims to characterize the Dummerstorf high-fertility mouse line FL1 on endocrine and molecular levels on the female side. We analyzed parameters of the hypothalamic pituitary gonadal axis on both hormonal and transcriptional levels. Gonadotropin-releasing

SUBMITTER: Ludwig CLM 

PROVIDER: S-EPMC9175557 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature