Long-term methimazole therapy in Graves' hyperthyroidism and adverse reactions: a Danish multicenter study.

ABSTRACT:

Purpose

In this prospective multicenter study with patients newly diagnosed with Graves' hyperthyroidism (GH), we studied the timing and characteristics of adverse drug reactions in patients treated with anti-thyroid drugs (ATD) for up to 48 months.

Methods

Patients with GH were treated with ATD until remission and hereafter with a low-dose regime to keep the patients in remission. The patients were followed with blood samples and recording of adverse events approximately every second month for the first 2 years and every third month for the following 2 years.

Results

We included 208 patients and the patients were treated for a median of 22 (range: 0.5-49) months. Ten percent of the patients experienced adverse drug reactions and 75% of the cases occurred during the f

SUBMITTER: Karmisholt J 

PROVIDER: S-EPMC9175582 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature