Updating the Comparative Evidence on Second-Generation Antipsychotic Use With Schizophrenia.

ABSTRACT:

Objective

The objective of this study was to conduct a systematic review of literature comparing second-generation antipsychotics (SGAs) with each other and with first-generation antipsychotics (FGAs) in treating schizophrenia.

Methods

MEDLINE, the Cochrane Library, and PsycINFO databases were searched through January 2020. Following standard methods, recent high-quality systematic reviews of each drug comparison and subsequently published primary studies were included to update the meta-analyses with any new data. Two reviewers independently conducted study selection, abstraction, and quality assessment.

Results

Two systematic reviews and 29 newer trials (total of 162 trials of SGAs, N=53,861; 116 trials of SGAs versus FGAs, N=119,558) were included. Most trials were

SUBMITTER: McDonagh MS 

PROVIDER: S-EPMC9175869 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature