Simultaneous determination of HCV genotype and NS5B resistance associated substitutions using dried serum spots from Sao Paulo state, Brazil.

ABSTRACT: Hepatitis C virus (HCV) is responsible for more than 180 million infections worldwide, and about 80 % of infections are reported in Low and Middle-income countries (LMICs). Therapy is based on the administration of interferon (INF), ribavirin (RBV) or more recently Direct-Acting Antivirals (DAAs). However, amino acid substitutions associated with resistance (RAS) have been extensively described and can contribute to treatment failure, and diagnosis of RAS requires considerable infrastructure, not always locally available. Dried serum spots (DSS) sampling is an alternative specimen collection method, which embeds drops of serum onto filter paper to be transported by posting to a centralized laboratory. Here, we assessed feasibility of genotypic analysis of HCV from DSS in a cohort of 80 pat

SUBMITTER: Adeboyejo K 

PROVIDER: S-EPMC9175972 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature