Ontology highlight
ABSTRACT:
SUBMITTER: Williams AP
PROVIDER: S-EPMC9176016 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Williams Anthony P AP Bate Jessica J Brooks Rachael R Chisholm Julia J Clarke Stuart C SC Dixon Elizabeth E Faust Saul N SN Galanopoulou Angeliki A Heath Paul T PT Maishman Thomas T Mapstone Susan S Patel Soonie R SR Vora Ajay A Wilding Sam A SA Gray Juliet C JC
EJHaem 20200610 1
Although survival rates for pediatric acute lymphoblastic leukemia are now excellent, this is at the expense of prolonged chemotherapy regimens. We report the long-term immune effects in children treated according to the UK Medical Research Council UKALL 2003 protocol. Peripheral blood lymphocyte subsets and immunoglobulin levels were studied in 116 participants, at six time points, during and for 18-month following treatment, with 30-39 patients analyzed at each time point. Total lymphocytes we ...[more]