The net benefit of thrombolysis in the management of intermediate risk pulmonary embolism: Systematic review and meta‐analysis

ABSTRACT: Abstract

Background

Benefit of thrombolytic therapy in patients with massive pulmonary embolism (PE) is evident. However, evidence supporting benefit in clinical outcomes of this approach in intermediate risk PE is lacking.

Objective

To determine the impact of thrombolysis on overall survival in intermediate risk PE patients.

Methods

We searched in MEDLINE (OVID), EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL) from present day. We also searched in other databases and unpublished literature. We included clinical trials without language restrictions. The risk of bias was evaluated with the Cochrane Collaboration's tool. The primary outcome was overall survival. Secondary outcomes were adverse events, including major bleeding, and a

SUBMITTER: Alcedo P 

PROVIDER: S-EPMC9176023 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature