Haematological malignancies in relatives of patients affected with myeloproliferative neoplasms.

ABSTRACT: In a cohort of 3131 patients with myeloproliferative neoplasms (MPNs), we identified 200 patients (6.4%) who reported a second case of haematological malignancies (HM) in first- or second-degree relatives. The occurrence of a second HM in the family was not influenced by MPN subtype, sex or driver mutation, while it was associated with age at MPN diagnosis: 8.5% of patients diagnosed with MPN younger than 45 years had a second relative affected with HM compared to 5.5% of those diagnosed at the age of 45 years or older (p = 0.003), thus suggesting a genetic predisposition to HM with early onset.

SUBMITTER: Vanni D 

PROVIDER: S-EPMC9176120 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature