Dietary fiber-based regulation of bile salt hydrolase activity in the gut microbiota and its relevance to human disease.

ABSTRACT: Complications of short bowel syndrome (SBS) include malabsorption and bacterial overgrowth, requiring prolonged dependence on parenteral nutrition (PN). We hypothesized that the intolerance of whole food in some SBS patients might be due to the effect of dietary fiber on the gut microbiome. Shotgun metagenomic sequencing and targeted metabolomics were performed using biospecimens collected from 55 children with SBS and a murine dietary fiber model. Bioinformatic analyses were performed on these datasets as well as from a healthy human dietary intervention study. Compared to healthy controls, the gut microbiota in SBS had lower diversity and increased Proteobacteria, a pattern most pronounced in children on PN and inversely correlated with whole food consumption. Whole food intake correlate

SUBMITTER: Kastl A 

PROVIDER: S-EPMC9176262 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature