Genomic and antigenic diversity of colonizing <i>Klebsiella pneumoniae</i> isolates mirrors that of invasive isolates in Blantyre, Malawi.

ABSTRACT: Members of the Klebsiella pneumoniae species complex, particularly K. pneumoniae subsp. pneumoniae are antimicrobial resistance (AMR) associated pathogens of global importance, and polyvalent vaccines targeting Klebsiella O-antigens are in development. Whole-genome sequencing has provided insight into O-antigen distribution in the K. pneumoniae species complex, as well as population structure and virulence determinants, but genomes from sub-Saharan Africa are underrepresented in global sequencing efforts. We therefore carried out a genomic analysis of extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae species complex isolates colonizing adults in Blantyre, Malawi. We placed these isolates in a global genomic context, and compare

SUBMITTER: Lewis JM 

PROVIDER: S-EPMC9176273 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature