Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.

ABSTRACT: Serratia marcescens is an important nosocomial pathogen causing various opportunistic infections, such as urinary tract infections, bacteremia and sometimes even hospital outbreaks. The recent emergence and spread of multidrug-resistant (MDR) strains further pose serious threats to global public health. This bacterium is also ubiquitously found in natural environments, but the genomic differences between clinical and environmental isolates are not clear, including those between S. marcescens and its close relatives. In this study, we performed a large-scale genome analysis of S. marcescens and closely related species (referred to as the 'S. marcescens complex'), including more than 200 clinical and environmental strains newly sequenced here. Our analysis reveale

SUBMITTER: Ono T 

PROVIDER: S-EPMC9176281 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature