A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number.

ABSTRACT: Tandem duplicated genes are common features of genomes, but the phenotypic consequences of their origins are not well understood. It is not known whether a simple doubling of gene expression should be expected, or else some other expression outcome. This study describes an experimental framework using engineered deletions to assess any contribution of locally acting cis- and globally acting trans-regulatory factors to expression interactions of particular tandem duplicated genes. Acsx1L (CG6300) and Acsx1R (CG11659) are tandem duplicates of a putative acyl-CoA synthetase gene found in Drosophila melanogaster. Experimental deletions of the duplicated segments were used to investigate whether the presence of 1 tandem duplicated block influences the expression of its neighbor. Acsx1L, the gen

SUBMITTER: Loehlin DW 

PROVIDER: S-EPMC9176294 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature