Myostain is involved in ginsenoside Rb1-mediated anti-obesity.

ABSTRACT:

Context

Obesity, one of the major public health problems worldwide, has attracted increasing attention. Ginsenoside Rb1 is the most abundant active component of Panax ginseng C.A.Mey (Araliaceae) and is reported to have beneficial effects on obesity and diabetes. However, the mechanisms by which Rb1 regulates obesity remain to be explored.

Objective

This paper intends to further explore the mechanism of Rb1 in regulating obesity.

Materials and methods

The C57BL/6 obese mice were divided into two groups: the control (CTR) and Rb1. The CTR group [intraperitoneally (ip) administered with saline] and the Rb1 group (ip administered with Rb1, 40 mg/kg/d) were treated daily for four weeks. In vitro, Rb1 (0, 10, 20, 40 μM) was added to differentiated C2C12 cells

SUBMITTER: Li HS 

PROVIDER: S-EPMC9176416 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature