SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis.

ABSTRACT: The ongoing COVID-19 pandemic is a major public health crisis. Despite the development and deployment of vaccines against SARS-CoV-2, the pandemic persists. The continued spread of the virus is largely driven by the emergence of viral variants, which can evade the current vaccines through mutations in the Spike protein. Although these differences in Spike are important in terms of transmission and vaccine responses, these variants possess mutations in the other parts of their genome which may affect pathogenesis. Of particular interest to us are the mutations present in the accessory genes, which have been shown to contribute to pathogenesis in the host through innate immune signaling, among other effects on host machinery. To examine the effects of accessory protein mutations and other no

SUBMITTER: McGrath ME 

PROVIDER: S-EPMC9176647 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature