The causal relationships between obstructive sleep apnea and elevated CRP and TNF-α protein levels.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) and inflammation are closely related. This study aimed to evaluate the associations and causal effect between C-reactive protein (CRP) and tumour necrosis factor-alpha (TNF-α) levels andOSA.

Methods

Pooled analysis was conducted to compare the expression differences of CRP and TNF-α between OSA patients with different severity and controls, and between continuous positive airway pressure (CPAP) and non-CPAP interventions for OSA patients. Using published GWAS summary statistics, we conducted a bidirectional two-sample Mendelian Randomization (MR) to estimate the causal relationships between CRP and TNF-α levels and OSA risk. Effect estimates were evaluated using inverse-variance weighted (IVW) as primary method, and several other MR m

SUBMITTER: Yi M 

PROVIDER: S-EPMC9176672 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature