Pathogenesis and transmission of human seasonal and swine-origin A(H1) influenza viruses in the ferret model.

ABSTRACT: Influenza A viruses (IAVs) in the swine reservoir constantly evolve, resulting in expanding genetic and antigenic diversity of strains that occasionally cause infections in humans and pose a threat of emerging as a strain capable of human-to-human transmission. For these reasons, there is an ongoing need for surveillance and characterization of newly emerging strains to aid pandemic preparedness efforts, particularly for the selection of candidate vaccine viruses and conducting risk assessments. Here, we performed a parallel comparison of the pathogenesis and transmission of genetically and antigenically diverse swine-origin A(H1N1) variant (v) and A(H1N2)v, and human seasonal A(H1N1)pdm09 IAVs using the ferret model. Both groups of viruses were capable of replication in the ferret upper r

SUBMITTER: Pulit-Penaloza JA 

PROVIDER: S-EPMC9176692 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature