Ontology highlight
ABSTRACT:
SUBMITTER: Garnier L
PROVIDER: S-EPMC9176743 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Garnier Laure L Pick Robert R Montorfani Julien J Sun Mengzhu M Brighouse Dale D Liaudet Nicolas N Kammertoens Thomas T Blankenstein Thomas T Page Nicolas N Bernier-Latamani Jeremiah J Tran Ngoc Lan NL Petrova Tatiana V TV Merkler Doron D Scheiermann Christoph C Hugues Stéphanie S
Science advances 20220608 23
Tumor-associated lymphatic vessels promote metastasis and regulate antitumor immune responses. Here, we assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response. Interferon-γ (IFN-γ) released by effector T cells enhanced the expression of immunosuppressive markers by tumor-associated lymphatic endothelial cells (LECs). However, at higher effector T cell densities within the tumor, T cell-based immunotherapies ind ...[more]