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Epidemiology beyond its limits.


ABSTRACT: In 1995, journalist Gary Taubes published an article in Science titled "Epidemiology faces its limits," which questioned the utility of nonrandomized epidemiologic research and has since been cited more than 1000 times. He highlighted numerous examples of research topics he viewed as having questionable merit. Studies have since accumulated for these associations. We systematically evaluated current evidence of 53 example associations discussed in the article. Approximately one-quarter of those presented as doubtful are now widely viewed as causal based on current evaluations of the public health consensus. They include associations between alcohol consumption and breast cancer, residential radon exposure and lung cancer, and the use of tanning devices and melanoma. This history should inform current debates about the reproducibility of epidemiologic research results.

SUBMITTER: McCullough LE 

PROVIDER: S-EPMC9176748 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Epidemiology beyond its limits.

McCullough Lauren E LE   Maliniak Maret L ML   Amin Avnika B AB   Baker Julia M JM   Baliashvili Davit D   Barberio Julie J   Barrera Chloe M CM   Brown Carolyn A CA   Collin Lindsay J LJ   Freedman Alexa A AA   Gibbs David C DC   Haddad Maryam B MB   Hall Eric W EW   Hamid Sarah S   Harrington Kristin R V KRV   Holleman Aaron M AM   Kaufman John A JA   Khan Mohammed A MA   Labgold Katie K   Lee Veronica C VC   Malik Amyn A AA   Mann Laura M LM   Marks Kristin J KJ   Nelson Kristin N KN   Quader Zerleen S ZS   Ross-Driscoll Katherine K   Sarkar Supriya S   Shah Monica P MP   Shao Iris Y IY   Smith Jonathan P JP   Stanhope Kaitlyn K KK   Valenzuela-Lara Marisol M   Van Dyke Miriam E ME   Vyas Kartavya J KJ   Lash Timothy L TL  

Science advances 20220608 23


In 1995, journalist Gary Taubes published an article in <i>Science</i> titled "Epidemiology faces its limits," which questioned the utility of nonrandomized epidemiologic research and has since been cited more than 1000 times. He highlighted numerous examples of research topics he viewed as having questionable merit. Studies have since accumulated for these associations. We systematically evaluated current evidence of 53 example associations discussed in the article. Approximately one-quarter of  ...[more]

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