Predicting severity of cartilage damage in a post-traumatic porcine model: Synovial fluid and gait in a support vector machine.

ABSTRACT: The inflammatory response to joint injury has been thought to play a key role in the development of osteoarthritis. In this preclinical study, we hypothesized that synovial fluid presence of inflammatory cytokines, as well as altered loading on the injured leg, would be associated with greater development of macroscopic cartilage damage after an ACL injury. Thirty-six Yucatan minipigs underwent ACL transection and were randomized to: 1) no further treatment, 2) ACL reconstruction, or 3) scaffold-enhanced ACL restoration. Synovial fluid samples and gait data were obtained pre-operatively and at multiple time points post-operatively. Cytokine levels were measured using a multiplex assay. Macroscopic cartilage assessments were performed following euthanasia at 52 weeks. General estimating equ

SUBMITTER: Donnenfield JI 

PROVIDER: S-EPMC9176756 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature