OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.

ABSTRACT: Animals detect changes in both their environment and their internal state and modify their behavior accordingly. Yet, it remains largely to be clarified how information of environment and internal state is integrated and how such integrated information modifies behavior. Well-fed C. elegans migrates to past cultivation temperature on a thermal gradient, which is disrupted when animals are starved. We recently reported that the neuronal activities synchronize between a thermosensory neuron AFD and an interneuron AIY, which is directly downstream of AFD, in well-fed animals, while this synchrony is disrupted in starved animals. However, it remained to be determined whether the disruption of the synchrony is derived from modulation of the transmitter release from AFD or from the modification

SUBMITTER: Aoki I 

PROVIDER: S-EPMC9176836 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature