Differential Abnormality in Functional Connectivity Density in Preclinical and Early-Stage Alzheimer's Disease.

ABSTRACT:

Background

Both subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) have a high risk of progression to Alzheimer's disease (AD). While most of the available evidence described changes in functional connectivity (FC) in SCD and aMCI, there was no confirmation of changes in functional connectivity density (FCD) that have not been confirmed. Therefore, the purpose of this study was to investigate the specific alterations in resting-state FCD in SCD and aMCI and further assess the extent to which these changes can distinguish the preclinical and early-stage AD.

Methods

A total of 57 patients with SCD, 59 patients with aMCI, and 78 healthy controls (HC) were included. The global FCD, local FCD, and long-range FCD were calculated for each voxel to iden

SUBMITTER: Song Y 

PROVIDER: S-EPMC9177137 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature