Analysis of copy number variations of the autosomal genome in 156 patients with azoospermia.

ABSTRACT:

Background

To analyze the relationship between copy number variations (CNVs) and azoospermia by analyzing the chromosome gene copy data of 156 patients with azoospermia.

Methods

A total of 156 azoospermia patients who were treated in our hospital from October 2018 to May 2021 were selected. Informed consent was signed, and semen analysis, testicular biopsy, and chromosome gene detection were carried out. CNVs were analyzed by next-generation sequencing (NGS) detection, and the obtained results were statistically analyzed.

Results

Among the 156 azoospermia patients, 81 cases had sperm in the testicular puncture and 75 cases had no sperm in the testicular puncture. There was a significant difference in CNV detection between the 2 groups (P<0.05). Detailed analysis of CN

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9177260 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature