Mechanism of ferroptosis in hypertensive nephropathy.

ABSTRACT:

Background

In recent years, it has been demonstrated that ferroptosis can be involved in a variety of kidney injury processes, but the role played by ferroptosis in hypertensive kidney injury is still unclear. The aim was to explore the mechanism of ferroptosis playing a role in hypertensive kidney disease and related signalling pathways.

Methods

GSE37455 microarray data was downloaded from the Gene Expression Omnibus (GEO) database and preprocessed. Batch correction and differential analysis were performed on the normal population and the hypertensive nephropathy samples using the "sva" and "limma" packages in R software. Ferroptosis-related genes were obtained from the FerrDb database and normalized and processed using UniProt. Ferroptosis-related differentially expressed

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9177265 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature