The longitudinal dynamics and natural history of clonal haematopoiesis.

ABSTRACT: Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis^1-4. The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited^5,6. Here we track 697 clonal haematopoiesis clones from 385 individuals 55 years of age or older over a median of 13 years. We find that 92.4% of clones expanded at a stable exponential rate over the study period, with different mutations driving substantially different growth rates, ranging from 5% (DNMT3A and TP53) to more than 50% per year (SRSF2^P95H). Growth rates

SUBMITTER: Fabre MA 

PROVIDER: S-EPMC9177423 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature