Prolonged viral suppression with anti-HIV-1 antibody therapy.

ABSTRACT: HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is effective but requires lifelong drug administration owing to a stable reservoir of latent proviruses integrated into the genome of CD4⁺ T cells¹. Immunotherapy with anti-HIV-1 antibodies has the potential to suppress infection and increase the rate of clearance of infected cells^2,3. Here we report on a clinical study in which people living with HIV received seven doses of a combination of two broadly neutralizing antibodies over 20 weeks in the presence or absence of ART. Without pre-screening for antibody sensitivity, 76% (13 out of 17) of the volunteers maintained virologic suppression for at least 20 weeks off ART. Post hoc sensitivity analyses were not predict

SUBMITTER: Gaebler C 

PROVIDER: S-EPMC9177424 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature