Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.

ABSTRACT: Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk; therefore, novel therapeutic candidates targeting inflammation are needed. The endothelium is the starting point of vascular inflammation underlying atherosclerosis and we could previously demonstrate that the chemokine axis CXCL12-CXCR4 plays an important role in disease development. However, the role of ACKR3, the alternative and higher affinity receptor for CXCL12 remained to be elucidated. We studied the role of arterial ACKR3 in atherosclerosis using western diet-fed Apoe^-/- mice lacking Ackr3 in arterial endothelial as well a

SUBMITTER: Gencer S 

PROVIDER: S-EPMC9177477 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature