Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.

ABSTRACT:

Background

Inhaled corticosteroid (ICS) response among patients with asthma is influenced by genetics, but biologically actionable insights based on associations have not been found. Various glucocorticoid response omics data sets are available to interrogate their biological effects.

Objective

We sought to identify functionally relevant ICS-response genetic associations by integrating complementary multiomics data sets.

Methods

Variants with P values less than 10^-4 from a previous ICS-response genome-wide association study were reranked on the basis of integrative scores determined from (1) glucocorticoid receptor- and (2) RNA polymerase II-binding regions inferred from ChIP-Seq data for 3 airway cell types, (3) glucocorticoid response element motifs, (4)

SUBMITTER: Kan M 

PROVIDER: S-EPMC9177524 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature