The incidence of and risk factors for hospitalized acute kidney injury among people living with HIV on antiretroviral treatment.

ABSTRACT:

Objectives

The epidemiology of hospitalized acute kidney injury (AKI) among people living with HIV (PLWH) in the era of modern antiretroviral therapy (ART) for all PLWH is not well characterized. We evaluated the incidence of and risk factors for hospitalized AKI from 2005 to 2015 among PLWH on ART.

Methods

We conducted a retrospective analysis of PLWH from the Johns Hopkins HIV Clinical Cohort. We defined hospitalized AKI as a rise of ≥ 0.3 mg/dL in serum creatinine (SCr) within any 48-h period or a 50% increase in SCr from baseline and assessed associations of risk factors with incident AKI using multivariate Cox regression models.

Results

Most participants (75%) were black, 34% were female, and the mean age was 43 years. The incidence of AKI fluctuated annually, pe

SUBMITTER: Muiru AN 

PROVIDER: S-EPMC9177550 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature