Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Duran I
PROVIDER: S-EPMC9177556 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Fernández-Duran Irene I Quintanilla Andrea A Tarrats Núria N Birch Jodie J Hari Priya P Millar Fraser R FR Lagnado Anthony B AB Smer-Barreto Vanessa V Muir Morwenna M Brunton Valerie G VG Passos João F JF Acosta Juan Carlos JC
Cell death and differentiation 20211216 6
Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis. Here we show that LPS-mediated activation of caspase-4 also induces a stress response promoting cellular senescence, which is dependent on the caspase-4 substrate gasdermin-D and the tumor suppressor p53. Furthermore, we found that the caspase-4 noncanonical inflammasome is induced an ...[more]