Lymphocyte Subset Ratio Cannot Diagnose Immune Failure of a TKA.

ABSTRACT:

Background

Up to 20% of patients are dissatisfied following total knee arthroplasty (TKA), most often due to pain and/or stiffness. The differential diagnosis includes immune reaction to the prosthesis. However, there is no consensus on diagnostic criteria for immune failure, an allergic reaction, to a TKA. Histologic evaluation could provide evidence as to whether an allergic reaction caused TKA failure. A recent study showed an increase in CD4+ lymphocytes compared to CD8+ lymphocytes in patients lymphocyte transformation testing (LTT) + for Ni. This finding is consistent with Ni sensitization, but can lymphocyte subsets be used to diagnose immune failure on a case-by-case basis?

Methods

Periprosthetic tissues from 18 revision cases of well-fixed, aseptic, but painful and/

SUBMITTER: Keeling P 

PROVIDER: S-EPMC9177629 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature