Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea.

ABSTRACT: Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic glucose rate (CMRgl) and cognitive function in patients with OSA. Patients with moderate to severe OSA were randomly assigned to ET (3 times/week, n = 23) or no intervention (control, n = 24). Echocardiography and apolipoprotein ε4 (APOEε4) genotyping were obtained at baseline. Both groups underwent cardiopulmonary exercise testing, polysomnography, cognitive tests, brain magnetic resonance imaging, and ¹⁸F-fluoro-2-deoxy-D-Glucose positron emission tomography (¹⁸FDG-PET) at baseline and study end. Compared with control, exercise-tr

SUBMITTER: Ueno-Pardi LM 

PROVIDER: S-EPMC9177702 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature