Hepatitis C coinfection and extrahepatic cancer incidence among people living with HIV.

ABSTRACT:

Objectives

We assessed the incidence of extrahepatic cancer among people with HIV/HCV coinfection and the potential impact of direct-acting antivirals (DAAs) on extrahepatic cancer risk among people with HIV/HCV coinfection.

Design

Our study cohort included adults who initiated HIV care at a CNICS site in the US during 1995-2017, excluding those with previous cancer and without HCV testing.

Methods

We used Cox regression to estimate hazard ratios for extrahepatic cancer incidence among patients with HIV/HCV coinfection compared with those with HIV monoinfection. Standardized morbidity ratio (SMR) weights were used to create a 'pseudopopulation' in which all patients were treated with antiretroviral therapy (ART), and to compare extrahepatic cancer incidence among pati

SUBMITTER: Willis SJ 

PROVIDER: S-EPMC9177743 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature