The roaring 2020s: a new decade of systemic therapy for renal cell carcinoma.

ABSTRACT:

Purpose of review

The genomic and immunologic profiling of renal cell carcinoma (RCC) has provided the impetus for advancements in systemic treatments using combination therapy - either with immune check point inhibitor (ICI) + ICI or with ICI + targeted therapy. This approach has been examined in several landmark trials, treating both clear cell (ccRCC) and nonclear cell (nccRCC) histologies. In this review, we highlight systemic therapy advancements made in this new decade, the 2020s.

Recent findings

Targeting the programmed death receptor 1/PD-L1 pathway has created more tolerable and effective immunotherapy regimens, expanding the applications of ICIs. These new applications, paired with trial data, include ICI monotherapy in nccRCC and adjuvant pembrolizumab in resected

SUBMITTER: Srivastava A 

PROVIDER: S-EPMC9177746 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature