Ontology highlight
ABSTRACT:
SUBMITTER: Shi Q
PROVIDER: S-EPMC9177840 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Shi Qing Q Jin Xiaofeng X Zhang Pingzhao P Li Qian Q Lv Zeheng Z Ding Yan Y He Huiying H Wang Yijun Y He Yuanlong Y Zhao Xiaying X Zhao Shi-Min SM Li Yao Y Gao Kun K Wang Chenji C
Cell death and differentiation 20220106 6
p62/SQSTM1 is a selective autophagy receptor that drives ubiquitinated cargos towards autophagic degradation. This receptor is also a stress-induced scaffold protein that helps cells to cope with oxidative stress through activation of the Nrf2 pathway. Functional disorders of p62 are closely associated with multiple neurodegenerative diseases and cancers. The gene encoding the E3 ubiquitin ligase substrate-binding adapter SPOP is frequently mutated in prostate cancer (PCa), but the molecular mec ...[more]