Photo and copper dual catalysis for allene syntheses from propargylic derivatives via one-electron process.

ABSTRACT: Different from the traditional two-electron oxidative addition-transmetalation-reductive elimination coupling strategy, visible light has been successfully integrated into transition metal-catalyzed coupling reaction of propargylic alcohol derivatives highly selectively forming allenenitriles: specifically speaking, visible light-mediated Cu-catalyzed cyanation of propargylic oxalates has been realized for the general, efficient, and exclusive syntheses of di-, tri, and tetra-substituted allenenitriles bearing various synthetically versatile functional groups. A set of mechanistic studies, including fluorescence quenching experiments, cyclic voltammetric measurements, radical trapping experiments, control experiments with different photocatalyst, and DFT calculation studies have proven tha

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9177964 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature